National Health (Listing of Pharmaceutical Benefits) Amendment Instrument 2016 (No. 4) (PB 29 of 2016) (Cth)

Case

PB 29 of 2016

National Health (Listing of Pharmaceutical Benefits) Amendment Instrument 2016
(No. 4)

National Health Act 1953

I, PENNY SHAKESPEARE, First Assistant Secretary, Pharmaceutical Benefits Division, Department of Health, delegate of the Minister for Health, make this Instrument under sections 84AF, 84AK, 85, 85A, 88 and 101 of the National Health Act 1953.

Dated    29 April   2016

PENNY SHAKESPEARE
First Assistant Secretary
Pharmaceutical Benefits Division
Department of Health


1          Name of Instrument

(1)        This Instrument is the National Health (Listing of Pharmaceutical    Benefits) Amendment Instrument 2016 (No. 4).

(2)        This Instrument may also be cited as PB 29 of 2016.

2          Commencement

This Instrument commences on 1 May 2016.

3          Amendment of National Health (Listing of Pharmaceutical Benefits) Instrument 2012 (PB 71 of 2012)

Schedule 1 amends the National Health (Listing of Pharmaceutical Benefits) Instrument 2012 (PB 71 of 2012).

Schedule 1     Amendments

  1. After Subsection 11(1)(d)

    insert:

    (1A)  If the circumstances mentioned in Part 1 of Schedule 4 for a circumstances code mentioned in Schedule 1 for the pharmaceutical benefit include the words ‘Compliance with Telephone Authority Required procedures’ or ‘Compliance with Written or Telephone Authority Required procedures’ treat as if the words used are  ‘Compliance with Authority Required procedures’.

    Note: If there is a Streamlined Authority Code section 14 continues to apply.

  2. Subsection 12(1), paragraph (d)

    substitute:

    (d)     the authorised prescriber submits details of the prescription in accordance with subsection 12(4A) to the Chief Executive Medicare,
    by means of electronic communication to obtain an electronic authority.

  3. After Subsection 12(4)

    insert:

    (4A)  The prescription submitted in accordance with paragraph 12(1)(d) must be:

    (a)   given to the Chief Executive Medicare in writing; and
    (b)   by means of an electronic communication; and
    (c)   encrypted when it is given to the Chief Executive Medicare; and
    (d)   in accordance with any other requirements that would need to be met in order for the requirements to give the
           information in writing to be taken to have been met under the Electronic Transactions Act 1999.

  1. Subsection 13(3)

    substitute:

    (3)     A prescription submitted in accordance with paragraph 12(1)(d) may be authorised by the Chief Executive Medicare sending
    his or her authorisation, by electronic communication, including computer automated electronic communication, to the authorised prescriber.

    (3A)  If the prescription submitted is declined for authorisation, the authorised prescriber may seek review of the decision by the Chief Executive Medicare.

  2. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled syringe [Maximum Quantity: 2; Number of Repeats: 0]

    (a)omit from the column headed “Circumstances”:               C4826  C4840 

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

  3. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled syringe [Maximum Quantity: 2; Number of Repeats: 2]

    (a)omit from the column headed “Circumstances”:               C4826  C4840 

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

  4. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled syringe [Maximum Quantity: 2; Number of Repeats: 3]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

    (d)omit from the column headed “Purposes”:         P4826 P4840

    (e)insert in numerical order:       P6069 P6092

  5. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled syringe [Maximum Quantity: 2; Number of Repeats: 4]

    (a)omit from the column headed “Circumstances”:               C4826  C4840 

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

  6. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled syringe [Maximum Quantity: 2; Number of Repeats: 5]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

    (d)omit from the column headed “Purposes”:         P4864

    (e)insert in numerical order:       P6081

  7. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled pen [Maximum Quantity: 2; Number of Repeats: 0]

    (a)omit from the column headed “Circumstances”:               C4826  C4840 

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

  8. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled pen [Maximum Quantity: 2; Number of Repeats: 2]

    (a)omit from the column headed “Circumstances”:               C4826  C4840 

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

  9. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled pen [Maximum Quantity: 2; Number of Repeats: 3]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

    (d)omit from the column headed “Purposes”:         P4826 P4840

    (e)insert in numerical order:       P6069 P6092

  10. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled pen [Maximum Quantity: 2; Number of Repeats: 4]

    (a)omit from the column headed “Circumstances”:               C4826  C4840 

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

  11. Schedule 1, entry for Adalimumab in the form Injection 40 mg in 0.8 mL pre-filled pen [Maximum Quantity: 2; Number of Repeats: 5]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092

    (d)omit from the column headed “Purposes”:         P4864

    (e)insert in numerical order:       P6081

  12. Schedule 1, omit entry for Aluminium Hydroxide with Magnesium Hydroxide

  13. Schedule 1, entry for Aripiprazole in each of the forms: Tablet 10 mg; Tablet 15 mg; Tablet 20 mg and Tablet 30 mg

    omit from the column headed “Circumstances”:          C1589   substitute:             C4246

  1. Schedule 1, entry for Auranofin

    omit:

Capsule 3 mg Oral Ridaura GH MP NP 60 5 60
  1. Schedule 1, after entry for Beclomethasone in the form Pressurised inhalation in breath actuated device containing beclomethasone dipropionate 100 micrograms per dose, 200 doses (CFC-free formulation)

    insert:

Bendamustine Powder for injection containing bendamustine hydrochloride
25 mg
Injection Ribomustin JC MP C6075 C6124 See Note 3 See Note 3 1 D(100)
Powder for injection containing bendamustine hydrochloride 100 mg Injection Ribomustin JC MP C6075 C6124 See Note 3 See Note 3 1 D(100)
  1. Schedule 1, after entry for Buprenorphine in the form Transdermal patch 10 mg

    insert:

Transdermal patch 15 mg Transdermal Norspan MF MP NP C4951 2 0 2
  1. Schedule 1, after entry for Buprenorphine in the form Transdermal patch 20 mg

    insert:

Transdermal patch 25 mg Transdermal Norspan MF MP NP C4951 2 0 2
Transdermal patch 30 mg Transdermal Norspan MF MP NP C4951 2 0 2
Transdermal patch 40 mg Transdermal Norspan MF MP NP C4951 2 0 2
  1. Schedule 1, entry for Carmellose

    omit:

Eye drops containing carmellose sodium 5 mg per mL, 15 mL Application to the eye Refresh Tears Plus AG MP C1362 C3036 P1362 1 5 1
NP AO C1362 1 5 1
MP C1362 C3036 P3036 1 11 1
Eye drops containing carmellose sodium 10 mg per mL, 15 mL Application to the eye Refresh Liquigel AG MP C1362 C3036 P1362 1 5 1
NP AO C1362 1 5 1
MP C1362 C3036 P3036 1 11 1

substitute:

Eye drops containing carmellose sodium 5 mg per mL, 15 mL Application to the eye Refresh Tears Plus AG AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
MP C6073 C6098 P6098 1 11 1
Eye drops containing carmellose sodium 10 mg per mL, 15 mL Application to the eye Refresh Liquigel AG AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
MP C6073 C6098 P6098 1 11 1
  1. Schedule 1, entry for Carmellose with glycerin

    substitute:

Carmellose with glycerin Eye drops containing carmellose sodium 5 mg with glycerin 9 mg per mL, 15 mL Application to the eye Optive AG AO C6097 1 3 1
MP C6072 C6079 P6072 1 3 1
NP C6072 1 3 1
MP C6072 C6079 P6079 1 7 1
  1. Schedule 1, entry for Certolizumab pegol

    (a)omit from the column headed “Circumstances”:               C4831  C4839  C4842  C4843

    (b)omit from the column headed “Circumstances”:               C4863

    (c)insert in numerical order:       C6068  C6109  C6126

  2. Schedule 1, entry for Cromoglycic Acid in the form Eye drops containing sodium cromoglycate 20 mg per mL, 10 mL

    omit from the column headed “Circumstances”:          C1466   substitute:             C6088

  3. Schedule 1, omit entry for Electrolyte Replacement, Solution

  4. Schedule 1, entry for Esomeprazole in the form Tablet (enteric coated) 20 mg (as magnesium trihydrate) [Maximum Quantity: 30; Number of Repeats: 1]

    insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

Nexazole RW MP NP C4988 C5029 C5030 C5039 P4988 30 1 30
  1. Schedule 1, entry for Esomeprazole in the form Tablet (enteric coated) 20 mg (as magnesium trihydrate) [Maximum Quantity: 30; Number of Repeats: 5]

    insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

Nexazole RW MP NP C4988 C5029 C5030 C5039 P5029 P5030 P5039 30 5 30
  1. Schedule 1, entry for Esomeprazole in the form Tablet (enteric coated) 40 mg (as magnesium trihydrate) [Maximum Quantity: 30; Number of Repeats: 1]

    insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

Nexazole RW MP NP C5011 C5021 C5028 P5028 30 1 30
  1. Schedule 1, entry for Esomeprazole in the form Tablet (enteric coated) 40 mg (as magnesium trihydrate) [Maximum Quantity: 30; Number of Repeats: 5]

    insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

Nexazole RW MP NP C5011 C5021 C5028 P5011 P5021 30 5 30
  1. Schedule 1, entry for Esomeprazole and Clarithromycin and Amoxycillin

    insert as first item in the columns in the order indicated:

Pack containing 14 tablets (enteric coated) containing esomeprazole 20 mg (as magnesium), 14 tablets clarithromycin 500 mg and 28 capsules amoxycillin 500 mg (as trihydrate) Oral ESOMEPRAZOLE SANDOZ Hp7 SZ MP NP C6118 1 0 1
  1. Schedule 1, entry for Esomeprazole and Clarithromycin and Amoxycillin in the form Pack containing 14 tablets (enteric coated) containing esomeprazole 20 mg (as magnesium trihydrate), 14 tablets clarithromycin 500 mg and 28 capsules amoxycillin 500 mg (as trihydrate)

    omit from the column headed “Circumstances”:          C5683   substitute:             C6118

  2. Schedule 1, entry for Etanercept in the form Injection 50 mg in 1 mL single use auto-injector, 4 [Maximum Quantity: 1;
    Number of Repeats: 3]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092 

    (d)omit from the column headed “Purposes”:      P4826 P4840

    (e)insert in numerical order:     P6069 P6092

  3. Schedule 1, entry for Etanercept in the form Injection 50 mg in 1 mL single use auto-injector, 4 [Maximum Quantity: 1;
    Number of Repeats: 5]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092 

    (d)omit from the column headed “Purposes”:      P4864

    (e)insert in numerical order:     P6081

  4. Schedule 1, entry for Etanercept in the form Injections 50 mg in 1 mL single use pre-filled syringes, 4 [Maximum Quantity: 1;
    Number of Repeats: 3]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092 

(d)omit from the column headed “Purposes”:      P4826 P4840

(e)insert in numerical order:     P6069 P6092

  1. Schedule 1, entry for Etanercept in the form Injections 50 mg in 1 mL single use pre-filled syringes, 4 [Maximum Quantity: 1;
    Number of Repeats: 5]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092 

    (d)omit from the column headed “Purposes”:      P4864

    (e)insert in numerical order:     P6081

  2. Schedule 1, entry for Etanercept in the form Injection set containing 4 vials powder for injection 25 mg and 4 pre-filled syringes solvent
    1 mL [Maximum Quantity: 2; Number of Repeats: 3]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092 

    (d)omit from the column headed “Purposes”:      P4826 P4840

    (e)insert in numerical order:     P6069 P6092

  3. Schedule 1, entry for Etanercept in the form Injection set containing 4 vials powder for injection 25 mg and 4 pre-filled syringes solvent
    1 mL [Maximum Quantity: 2; Number of Repeats: 5]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069  C6081  C6092 

    (d)omit from the column headed “Purposes”:      P4864

    (e)insert in numerical order:     P6081

  4. Schedule 1, entry for Fludarabine in the form Powder for I.V. injection containing fludarabine phosphate 50 mg

    (a)omit from the column headed “Brand”:               Fludara            substitute:             Fludarabine ACT

    (b)omit from the column headed “Responsible Person”:      GZ        substitute:             EA

    (c)omit from the column headed “Pack Quantity”:                                5          substitute:             1

  5. Schedule 1, omit entry for Glucose

  6. Schedule 1, omit entry for Glycerol

  1. Schedule 1, entry for Glycomacropeptide and essential amino acids with vitamins and minerals

    omit:

Sachets containing oral powder 49 g, 28 (Camino Pro Bettermilk) Oral Camino Pro Bettermilk QH MP NP C4295 4 5 1
  1. Schedule 1, entry for Golimumab in the form Injection 50 mg in 0.5 mL single use pre-filled syringe [Maximum Quantity: 1;
    Number of Repeats: 3]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069 C6081 C6092 

    (d)omit from the column headed “Purposes”:      P4826 P4840

    (e)insert in numerical order:     P6069 P6092

  2. Schedule 1, entry for Golimumab in the form Injection 50 mg in 0.5 mL single use pre-filled syringe [Maximum Quantity: 1;
    Number of Repeats: 5]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069 C6081 C6092 

    (d)omit from the column headed “Purposes”:      P4864

    (e)insert in numerical order:     P6081 

  3. Schedule 1, entry for Golimumab in the form Injection 50 mg in 0.5 mL single use pre-filled pen [Maximum Quantity: 1;
    Number of Repeats: 3]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069 C6081 C6092 

    (d)omit from the column headed “Purposes”:      P4826 P4840

    (e)insert in numerical order:     P6069 P6092

  4. Schedule 1, entry for Golimumab in the form Injection 50 mg in 0.5 mL single use pre-filled pen [Maximum Quantity: 1;
    Number of Repeats: 5]

    (a)omit from the column headed “Circumstances”:               C4826  C4840

    (b)omit from the column headed “Circumstances”:               C4864

    (c)insert in numerical order:       C6069 C6081 C6092 

    (d)omit from the column headed “Purposes”:      P4864

    (e)insert in numerical order:     P6081 

  5. Schedule 1, entry for Hypromellose

    substitute:

Hypromellose Eye drops 3 mg per mL, 15 mL Application to the eye a Genteal AQ AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
a In a Wink Moisturising IQ AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
a Genteal AQ MP C6073 C6098 P6098 1 11 1
a In a Wink Moisturising IQ MP C6073 C6098 P6098 1 11 1
Eye drops 5 mg per mL, 15 mL Application to the eye Methopt QA MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
AO C6120 1 5 1
MP C6073 C6098 P6098 1 11 1
  1. Schedule 1, entry for Hypromellose with Carbomer 980

    substitute:

Hypromellose with Carbomer 980 Ocular lubricating gel 3 mg‑2 mg per g, 10 g Application to the eye a Genteal gel AQ AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
a HPMC PAA IQ AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
a Genteal gel AQ MP C6073 C6098 P6098 1 11 1
a HPMC PAA IQ MP C6073 C6098 P6098 1 11 1
  1. Schedule 1, entry for Hypromellose with Dextran

    substitute:

Hypromellose with dextran Eye drops containing 3 mg hypromellose 2900 with 1 mg dextran 70 per mL, single dose units 0.4 mL, 28 Application to the eye Bion Tears AQ AO C2802 3 5 1
MP NP C1359 3 5 1
Eye drops containing 3 mg hypromellose 4500 with 1 mg dextran 70 per mL, 15 mL Application to the eye a Poly-Tears IQ MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
AO C6120 1 5 1
a Tears Naturale AQ MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
AO C6120 1 5 1
a Poly-Tears IQ MP C6073 C6098 P6098 1 11 1
a Tears Naturale AQ MP C6073 C6098 P6098 1 11 1
  1. Schedule 1, entry for Irinotecan in each of the forms: I.V. injection containing irinotecan hydrochloride trihydrate 40 mg in 2 mL; and
    I.V. injection containing irinotecan hydrochloride trihydrate 100 mg in 5 mL

    insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

IRINOTECAN ACT ED MP See Note 3 See
Note 3
1 D(100)
  1. Schedule 1, entry for Irinotecan in the form I.V. injection containing irinotecan hydrochloride trihydrate 500 mg in 25 mL

    (a)insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

IRINOTECAN ACT ED MP See Note 3 See
Note 3
1 D(100)

(b)omit:

Tecan ED MP See Note 3 See
Note 3
1 D(100)
  1. Schedule 1, entry for Lapatinib

    omit from the column headed “Circumstances”:          C5040   substitute:             C6105

  2. Schedule 1, after entry for Methotrexate

    substitute:

Methotrexate Injection 5 mg in 2 mL vial Injection Hospira Pty Limited HH MP 5 0 5
MP P3925

See Note 2 See Note 2 5 C(100)
Injection 50 mg in 2 mL vial Injection a Methaccord EA MP 5 5 1
a Methotrexate MYX YN MP 5 5 1
a Hospira Pty Limited HH MP 5 5 5
Methaccord EA MP P3925 See Note 2 See Note 2 1 C(100)
Methotrexate MYX YN MP P3925 See Note 2 See Note 2 1 C(100)
Hospira Pty Limited HH MP P3925 See Note 2 See Note 2 5 C(100)
Solution concentrate for I.V. infusion 500 mg in 20 mL vial Injection Hospira Pty Limited HH MP C3925 See Note 3 See Note 3 1 PB(100)
Solution concentrate for I.V. infusion 1000 mg in 10 mL vial Injection Hospira Pty Limited HH MP C3925 See Note 3 See Note 3 1 PB(100)
Methaccord EA MP C3925 See Note 3 See Note 3 1 PB(100)
Methotrexate MYX YN MP C3925 See Note 3 See Note 3 1 PB(100)
Solution concentrate for I.V. infusion 5000 mg in 50 mL vial Injection Methotrexate Ebewe SZ MP C3925 See Note 3 See Note 3 1 PB(100)
Tablet 2.5 mg Oral Methoblastin PF MP 30 5 30
Tablet 10 mg Oral Methoblastin PF MP 15 3 15
MP P5648 50 2 50
  1. Schedule 1, after entry for Metoclopramide in the form Injection containing metoclopramide hydrochloride 10 mg in 2 mL

    insert in the columns in the order indicated:

MP NP P6084 40
CN6084
0
CN6084
10
  1. Schedule 1, after entry for Nitrofurantoin in the form Capsule 100 mg

    insert:

Nivolumab Injection concentrate for I.V. infusion 40 mg in 4 mL Injection Opdivo BQ MP C6070 C6083 C6095 C6111 C6116 See Note 3 See Note 3 1 D(100)
Injection concentrate for I.V. infusion 100 mg in 10 mL Injection Opdivo BQ MP C6070 C6083 C6095 C6111 C6116 See Note 3 See Note 3 1 D(100)
  1. Schedule 1, entry for Norethisterone in the form Tablets 350 micrograms, 28

    omit:

Micronor JC MP NP 4 2 4
  1. Schedule 1, entry for Oestradiol in each of the forms: Transdermal patches 750 micrograms (as hemihydrate), 8; Transdermal patches
    1.5 mg (as hemihydrate), 8; and Transdermal patches 3 mg (as hemihydrate), 8

    omit from the column headed “Responsible Person” for the brands “Estraderm MX 25, “Estraderm MX 50” and Estraderm MX 100” respectively:               NV        substitute:             JU

  2. Schedule 1, entry for Ondansetron in the form Tablet 4 mg (as hydrochloride dihydrate)

    (a)omit:

a Ondaz SZ MP NP C4102 C4118 P4118 4 0 4
MP C5778 4 0 4 C(100)

(b)omit:

a Ondaz SZ MP NP C4102 C4118 P4102 10 1 10
  1. Schedule 1, entry for Ondansetron in the form Tablet 8 mg (as hydrochloride dihydrate)

    (a)omit:

a Ondaz SZ MP NP C4102 C4118 P4118 4 0 4
MP C5778 4 0 4 C(100)

(b)omit:

a Ondaz SZ MP NP C4102 C4118 P4102 10 1 10
  1. Schedule 1, entry for Ondansetron in the form Wafer 4 mg

    (a)omit:

Ondaz Zydis SZ MP NP C5618 C5777 P5618 4 0 4
MP C5743 4 0 4 C(100)

(b)omit:

Ondaz Zydis SZ MP NP C5618 C5777 P5777 10 1 10
  1. Schedule 1, entry for Ondansetron in the form Wafer 8 mg

    (a)omit:

Ondaz Zydis SZ MP NP C5618 C5777 P5618 4 0 4
MP C5743 4 0 4 C(100)

(b)omit:

Ondaz Zydis SZ MP NP C5618 C5777 P5777 10 1 10
  1. Schedule 1, entry for Oxycodone with naloxone

    insert as first item in the columns in the order indicated:

Tablet (controlled release) containing oxycodone hydrochloride 2.5 mg with naloxone hydrochloride 1.25 mg Oral Targin 2.5/1.25mg MF MP NP C4951 28 0 28
  1. Schedule 1, after entry for Oxycodone with naloxone in the form Tablet (controlled release) containing oxycodone hydrochloride 10 mg with naloxone hydrochloride 5 mg

    insert in the columns in the order indicated:

Tablet (controlled release) containing oxycodone hydrochloride 15 mg with naloxone hydrochloride 7.5 mg Oral Targin 15/7.5mg MF MP NP C4951 28 0 28
  1. Schedule 1, after entry for Oxycodone with naloxone in the form Tablet (controlled release) containing oxycodone hydrochloride 20 mg with naloxone hydrochloride 10 mg

    insert in the columns in the order indicated:

Tablet (controlled release) containing oxycodone hydrochloride 30 mg with naloxone hydrochloride 15 mg Oral Targin 30/15mg MF MP NP C4951 28 0 28
  1. Schedule 1, entry for Paclitaxel, nanoparticle albumin-bound

    (a)omit from the column headed “Circumstances”:               C3955  C3956

    (b)insert in numerical order:       C6106  C6119

  2. Schedule 1, entry for Paraffin in the form Pack containing 2 tubes eye ointment, compound, containing white soft paraffin with liquid paraffin, 3.5 g

    omit from the column headed “Purposes” (all instances):         P3035   substitute:             P4894

  3. Schedule 1, after entry for Paraffin in the form Pack containing 2 tubes eye ointment, compound, containing white soft paraffin with liquid paraffin, 3.5 g [Brand: Poly Visc; Maximum Quantity: 1; Number of Repeats: 11]

    insert:

Paritaprevir with ritonavir with ombitasvir and dasabuvir Pack containing 56 tablets paritaprevir 75 mg with ritonavir 50 mg with ombitasvir 12.5 mg and 56 tablets dasabuvir 250 mg Oral Veikira Pak VE MP C5969 1 2 1
Paritaprevir with ritonavir with ombitasvir and dasabuvir and ribavirin Pack containing 56 tablets paritaprevir 75 mg with ritonavir 50 mg with ombitasvir 12.5 mg and 56 tablets dasabuvir 250 mg and 56 tablets ribavirin 600 mg Oral Viekira Pak-RBV VE MP C6130 C6131 P6131 1 2 1
MP C6130 C6131 P6130 1 5 1
Pack containing 56 tablets paritaprevir 75 mg with ritonavir 50 mg with ombitasvir 12.5 mg and 56 tablets dasabuvir 250 mg and 168 tablets ribavirin 200 mg Oral Viekira Pak-RBV VE MP C6130 C6131 P6131 1 2 1
MP C6130 C6131 P6130 1 5 1
  1. Schedule 1, entry for Pembrolizumab

    substitute:

Pembrolizumab Powder for injection 50 mg Injection Keytruda MK MP C5362 C6093 C6094 C6103 C6104 See Note 3 See Note 3 1 D(100)
  1. Schedule 1, entry for Pioglitazone in the form Tablet 15 mg (as hydrochloride)

    omit:

a Pioglitazone generichealth 15 GQ MP NP C4363 C4364 C4388 28 5 28
  1. Schedule 1, entry for Pioglitazone in the form Tablet 30 mg (as hydrochloride)

    omit:

a Pioglitazone generichealth 30 GQ MP NP C4363 C4364 C4388 28 5 28
  1. Schedule 1, entry for Pioglitazone in the form Tablet 45 mg (as hydrochloride)

    omit:

a Pioglitazone generichealth 45 GQ MP NP C4363 C4364 C4388 28 5 28
  1. Schedule 1, entry for Polyethylene Glycol 400 with Propylene Glycol

    omit:

Eye drops 4 mg‑3 mg per mL, 15 mL Application to the eye Systane AQ MP C1362 C3036 P1362 1 5 1
NP AO C1362 1 5 1
MP C1362 C3036 P3036 1 11 1

substitute:

Eye drops 4 mg‑3 mg per mL, 15 mL Application to the eye Systane AQ AO C6120 1 5 1
MP C6073 C6098 P6073

1 5 1
NP C6073 1 5 1
MP C6073 C6098 P6098 1

11 1
  1. Schedule 1, entry for Polyvinyl Alcohol

    substitute:

Polyvinyl alcohol Eye drops 14 mg per mL, 15 mL Application to the eye a Liquifilm Tears AG MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
AO C6120 1 5 1
a PVA Tears PE MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
AO C6120 1 5 1
a Liquifilm Tears AG MP C6073 C6098 P6098 1 11 1
a PVA Tears PE MP C6073 C6098 P6098 1 11 1
Eye drops 14 mg per mL, 15 mL (contains sodium chlorite/hydrogen peroxide as preservative) Application to the eye Vistil AE AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
MP C6073 C6098 P6098 1 11 1
Eye drops 30 mg per mL, 15 mL (contains sodium chlorite/hydrogen peroxide as preservative) Application to the eye Vistil Forte AE AO C6120 1 5 1
MP C6073 C6098 P6073 1 5 1
NP C6073 1 5 1
MP C6073 C6098 P6098 1 11 1
  1. Schedule 1, entry for Prednisolone with Phenylephrine

    substitute:

Prednisolone with phenylephrine Eye drops containing prednisolone acetate 10 mg with phenylephrine hydrochloride 1.2 mg per mL, 10 mL Application to the eye Prednefrin Forte AG AO C6087 1 0 1
MP NP C6080 C6101 1 2 1
  1. Schedule 1, entry for Prochlorperazine

    omit:

Suppositories containing prochlorperazine equivalent to 25 mg prochlorperazine maleate, 5 Rectal Stemetil SW PDP 1 0 1
MP NP 1 2 1
  1. Schedule 1, entry for Ramipril

    omit:

Pack containing 7 tablets 2.5 mg, 21 tablets 5 mg and 10 capsules 10 mg Oral Tritace Titration Pack SW MP NP 1 0 1
  1. Schedule 1, entry for Risperidone

    (a)omit:

Tablet 0.5 mg (orally disintegrating) Oral Risperdal Quicklet JC MP NP C4246 C5897 C5898 C5916 P5897 P5898 P5916 56 2 28
MP NP C4246 C5897 C5898 C5916 P4246 56 5 28

(b)omit:

Tablet 1 mg (orally disintegrating) Oral Risperdal Quicklet JC MP NP C4246 C5897 C5898 C5907 C5916 P5897 P5898 P5916 56 2 28
MP NP C4246 C5897 C5898 C5907 C5916 P4246 P5907 56 5 28

(c)omit:

Tablet 2 mg (orally disintegrating) Oral Risperdal Quicklet JC MP NP C4246 C5898 C5907 C5916 P5898 P5916 56 2 28
MP NP C4246 C5898 C5907 C5916 P4246 P5907 56 5 28

(d)omit:

Tablet 3 mg (orally disintegrating) Oral Risperdal Quicklet JC MP NP C4246 C5907 56 5 28

(e)omit:

Tablet 4 mg (orally disintegrating) Oral Risperdal Quicklet JC MP NP C4246 C5907 56 5 28
  1. Schedule 1, entry for Rituximab in the form Solution for I.V. infusion 100 mg in 10 mL

    omit:

MP C4706 C5980 C5998 C6001 C6009 C6034 C6039 C6040 C6058 See Note 3 See Note 3 See
Note 3
2 PB(100)

substitute:

MP C4706 C5980 C5998 C6001 C6009 C6034 C6039 C6040 C6058 See Note 2 See
Note 2
2 PB(100)
  1. Schedule 1, entry for Rituximab in the form Solution for I.V. infusion 500 mg in 50 mL

    omit:

MP C4706 C5980 C5998 C6001 C6009 C6034 C6039 C6040 C6058 See Note 3 See Note 3 See
Note 3
1 PB(100)

substitute:

MP C4706 C5980 C5998 C6001 C6009 C6034 C6039 C6040 C6058 See Note 2 See
Note 2
1 PB(100)
  1. Schedule 1, entry for Rizatriptan in the form Tablet (orally disintegrating) 10 mg (as benzoate)

    (a)insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

APO-Rizatriptan TX MP NP C5708 4 5 2

(b)insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

Chem mart Rizatriptan CH MP NP C5708 4 5 2

(c)insert in the columns in the order indicated, and in alphabetical order for the column headed “Brand”:

Terry White Chemists Rizatriptan TW MP NP C5708 4 5 2
  1. Schedule 1, omit entry for Sodium Chloride

  2. Schedule 1, omit entry for Sodium Chloride with Glucose

  3. Schedule 1, omit entry for Sodium Lactate Compound

  4. Schedule 1, omit entry for Tiludronic Acid

  1. Schedule 1, entry for Trastuzumab emtansine in each of the forms: Powder for I.V. infusion 100 mg; and Powder for I.V. infusion 160 mg

    omit from the column headed “Circumstances”:          C4987   substitute:             C6096  C6129

  2. Schedule 1, entry for Ustekinumab in the form Injection 45 mg in 0.5 mL [Maximum Quantity: 1; Number of Repeats: 1]

    (a)insert in numerical order in the column headed “Circumstances”:               C6067  C6091  C6108  C6125

    (b)insert in numerical order in the column headed “Purposes”:         P6067 P6125

  3. Schedule 1, entry for Ustekinumab in the form Injection 45 mg in 0.5 mL [Maximum Quantity: 1; Number of Repeats: 2]

    (a)insert in numerical order in the column headed “Circumstances”:               C6067  C6091  C6108  C6125

    (b)insert in numerical order in the column headed “Purposes”:         P6091 P6108

  4. Schedule 1, entry for Verteporfin

    omit from the column headed “Circumstances”:          C3795  C3860  C3861    substitute:             C6099  C6100  C6121

  5. Schedule 4, Part 1, entry for Adalimumab

    (a)omit:

C4826 P4826

Severe psoriatic arthritis

Initial treatment – Initial 1 (new patient or patient recommencing treatment after a break of 5 years or more)

Patient must have severe active psoriatic arthritis; AND
Patient must have received no prior PBS-subsidised treatment with a biological agent for this condition; OR
Patient must have received no PBS-subsidised treatment with a biological agent for at least 5 years if they have previously received PBS-subsidised treatment with a biological agent for this condition; AND
Patient must have failed to achieve an adequate response to methotrexate at a dose of at least 20 mg weekly for a minimum period of 3 months; AND
Patient must have failed to achieve an adequate response to sulfasalazine at a dose of at least 2 g per day for a minimum period of 3 months; OR
Patient must have failed to achieve an adequate response to leflunomide at a dose of up to 20 mg daily for a minimum period of 3 months; AND
Patient must not receive more than 16 weeks of treatment under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab.
Where treatment with methotrexate, sulfasalazine or leflunomide is contraindicated according to the relevant TGA-approved Product Information, details must be provided at the time of application

Where intolerance to treatment with methotrexate, sulfasalazine or leflunomide developed during the relevant period of use, which was of a severity to necessitate permanent treatment withdrawal, details of the degree of this toxicity must be provided at the time of application

The following initiation criteria indicate failure to achieve an adequate response and must be demonstrated in all patients at the time of the initial application:
an elevated erythrocyte sedimentation rate (ESR) greater than 25 mm per hour or a C-reactive protein (CRP) level greater than 15 mg per L; and either
(a) an active joint count of at least 20 active (swollen and tender) joints; or
(b) at least 4 active joints from the following list of major joints:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

If the above requirement to demonstrate an elevated ESR or CRP cannot be met, the application must state the reasons why this criterion cannot be satisfied

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement

Compliance with Written Authority Required procedures


C4840 P4840

Severe psoriatic arthritis

Initial treatment – Initial 2 (change or recommencement of treatment)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received prior PBS-subsidised treatment with a biological agent for this condition in this Treatment Cycle; AND
Patient must not have already failed, or ceased to respond to, PBS-subsidised treatment with 3 biological agents within this Treatment Cycle; AND
Patient must not have failed, or ceased to respond to, PBS-subsidised treatment with this drug during the current Treatment Cycle; AND
Patient must not receive more than 16 weeks of treatment under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form

Applications for a patient who has previously received PBS-subsidised treatment with this drug within this Treatment Cycle and who wishes to recommence therapy with this drug within this same Cycle, must be accompanied by evidence of a response to the patient's most recent course of PBS-subsidised treatment with this drug

Where the most recent course of PBS-subsidised treatment was approved under either of the initial treatment restrictions (i.e. for patients with no prior PBS-subsidised biological therapy or, under this restriction, for patients who have received previous PBS-subsidised biological therapy), the patient must have been assessed for response following a minimum of 12 weeks of therapy. This assessment must have been submitted no later than 4 weeks from the date that course was ceased

Where the most recent course of PBS-subsidised treatment with this drug was approved under the continuing treatment criteria, the patient must have been assessed for response, and the assessment submitted no later than 4 weeks from the date that course was ceased

Where a response assessment was not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment

An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

Compliance with Written Authority Required procedures


(b)omit:

C4864 P4864

Severe psoriatic arthritis

Continuing treatment

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received this drug as their most recent course of PBS-subsidised treatment with a biological agent for this condition in the current Treatment Cycle; AND
Patient must demonstrate, at the time of application, an adequate response to treatment with this drug; AND
Patient must not receive more than 24 weeks of treatment per continuing treatment course authorised under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab

An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

The same indices of disease severity used to establish baseline at the commencement of treatment with each initial treatment application must be provided for all subsequent continuing treatment applications

All applications for continuing treatment with this drug must include a measurement of response to the most recent course of PBS-subsidised therapy. This assessment must be submitted no later than 4 weeks from the cessation of that treatment course. If the application is the first application for continuing treatment with this drug, it must be accompanied by an assessment of response to a minimum of 12 weeks of treatment with the initial treatment course

Where a response assessment is not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment with this drug

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form

Compliance with Written Authority Required procedures


(c)insert in numerical order after existing text

C6069 P6069

Severe psoriatic arthritis

Initial treatment – Initial 1 (new patient or patient recommencing treatment after a break of 5 years or more)

Patient must have severe active psoriatic arthritis; AND
Patient must have received no prior PBS-subsidised treatment with a biological agent for this condition; OR
Patient must have received no PBS-subsidised treatment with a biological agent for at least 5 years if they have previously received PBS-subsidised treatment with a biological agent for this condition; AND
Patient must have failed to achieve an adequate response to methotrexate at a dose of at least 20 mg weekly for a minimum period of 3 months; AND
Patient must have failed to achieve an adequate response to sulfasalazine at a dose of at least 2 g per day for a minimum period of 3 months; OR
Patient must have failed to achieve an adequate response to leflunomide at a dose of up to 20 mg daily for a minimum period of 3 months; AND
Patient must not receive more than 16 weeks of treatment under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
Where treatment with methotrexate, sulfasalazine or leflunomide is contraindicated according to the relevant TGA-approved Product Information, details must be provided at the time of application.
Where intolerance to treatment with methotrexate, sulfasalazine or leflunomide developed during the relevant period of use, which was of a severity to necessitate permanent treatment withdrawal, details of the degree of this toxicity must be provided at the time of application.
The following initiation criteria indicate failure to achieve an adequate response and must be demonstrated in all patients at the time of the initial application:
an elevated erythrocyte sedimentation rate (ESR) greater than 25 mm per hour or a C-reactive protein (CRP) level greater than 15 mg per L; and
either
(a) an active joint count of at least 20 active (swollen and tender) joints; or
(b) at least 4 active joints from the following list of major joints:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).
If the above requirement to demonstrate an elevated ESR or CRP cannot be met, the application must state the reasons why this criterion cannot be satisfied.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement.

Compliance with Written Authority Required procedures
C6081 P6081

Severe psoriatic arthritis

Continuing treatment

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received this drug as their most recent course of PBS-subsidised treatment with a biological agent for this condition in the current Treatment Cycle; AND
Patient must demonstrate, at the time of application, an adequate response to treatment with this drug; AND
Patient must not receive more than 24 weeks of treatment per continuing treatment course authorised under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and
either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).
The same indices of disease severity used to establish baseline at the commencement of treatment with each initial treatment application must be provided for all subsequent continuing treatment applications.
All applications for continuing treatment with this drug must include a measurement of response to the most recent course of PBS-subsidised therapy. This assessment must be submitted no later than 4 weeks from the cessation of that treatment course. If the application is the first application for continuing treatment with this drug, it must be accompanied by an assessment of response to a minimum of 12 weeks of treatment with the initial treatment course.
Where a response assessment is not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment with this drug.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form.

Compliance with Written Authority Required procedures
C6092 P6092

Severe psoriatic arthritis

Initial treatment – Initial 2 (change or recommencement of treatment)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received prior PBS-subsidised treatment with a biological agent for this condition in this Treatment Cycle; AND
Patient must not have already failed, or ceased to respond to, PBS-subsidised treatment with 3 biological agents within this Treatment Cycle; AND
Patient must not have failed, or ceased to respond to, PBS-subsidised treatment with this drug during the current Treatment Cycle; AND
Patient must not receive more than 16 weeks of treatment under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form.
Applications for a patient who has previously received PBS-subsidised treatment with this drug within this Treatment Cycle and who wishes to recommence therapy with this drug within this same Cycle, must be accompanied by evidence of a response to the patient's most recent course of PBS-subsidised treatment with this drug.
Where the most recent course of PBS-subsidised treatment was approved under either of the initial treatment restrictions (i.e. for patients with no prior PBS-subsidised biological therapy or, under this restriction, for patients who have received previous PBS-subsidised biological therapy), the patient must have been assessed for response following a minimum of 12 weeks of therapy. This assessment must have been submitted no later than 4 weeks from the date that course was ceased.
Where the most recent course of PBS-subsidised treatment with this drug was approved under the continuing treatment criteria, the patient must have been assessed for response, and the assessment submitted no later than 4 weeks from the date that course was ceased.
Where a response assessment was not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment.
An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and
either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).

Compliance with Written Authority Required procedures
  1. Schedule 4, Part 1, omit entry for Aluminium hydroxide with magnesium hydroxide

  1. Schedule 4, Part 1, entry for Aripiprazole

    substitute:

Aripiprazole C4246 Schizophrenia

Compliance with Authority Required procedures - Streamlined Authority Code 4246
  1. Schedule 4, Part 1, after entry for Beclomethasone

    insert:

Bendamustine C6075

Previously untreated stage III or IV indolent CD20 positive non-Hodgkin's lymphoma

Induction treatment

The treatment must be in combination with rituximab; AND
The condition must be previously untreated; AND
The condition must be symptomatic; AND
The treatment must be for induction treatment purposes only; AND
Patient must not receive more than 6 cycles (12 doses) of treatment under this restriction.

Compliance with Authority Required procedures - Streamlined Authority Code 6075
C6124

Previously untreated stage III or IV CD20 positive mantle cell lymphoma

Induction treatment

The treatment must be in combination with rituximab; AND
The condition must be previously untreated; AND
The condition must be symptomatic; AND
The treatment must be for induction treatment purposes only; AND
Patient must not receive more than 6 cycles (12 doses) of treatment under this restriction; AND
Patient must not be eligible for stem cell transplantation.

Compliance with Authority Required procedures - Streamlined Authority Code 6124
  1. Schedule 4, Part 1, entry for Carmellose

    (a)omit:

C1362 P1362 Severe dry eye syndrome, including Sjogren’s syndrome.

(b)omit:

C3036 P3036 For use in patients who have severe dry eye syndrome, including Sjogren’s syndrome, and who are receiving treatment under a GP Management Plan or Team Care Arrangements where Medicare benefits were or are payable for the preparation of the Plan or coordination of the Arrangements

(c)insert in numerical order after existing text:

C6073 P6073 Severe dry eye syndrome, including Sjogren's syndrome
C6098 P6098

Severe dry eye syndrome, including Sjogren's syndrome

Patient must be receiving treatment under a GP Management Plan or Team Care Arrangements where Medicare benefits were or are payable for the preparation of the Plan or coordination of the Arrangements.

C6120 Severe dry eye syndrome, including Sjogren's syndrome
  1. Schedule 4, Part 1, entry for Carmellose with glycerin

    substitute:

Carmellose with glycerin C6072 P6072 Severe dry eye syndrome, including Sjogren's syndrome
C6079 P6079 Severe dry eye syndrome, including Sjogren's syndrome
Patient must be receiving treatment under a GP Management Plan or Team Care Arrangements where Medicare benefits were or are payable for the preparation of the Plan or coordination of the Arrangements.
C6097 Severe dry eye syndrome, including Sjogren's syndrome
  1. Schedule 4, Part 1, entry for Certolizumab pegol

    (a)omit:

C4831

Severe psoriatic arthritis

Initial treatment - Initial 3 (initial PBS-subsidised supply for continuing treatment in a patient commenced on non-PBS-subsidised therapy) - balance of supply

Patient must have received insufficient therapy with this drug under the Initial 3 (initial PBS-subsidised supply for continuing treatment in a patient commenced on non-PBS-subsidised therapy) restriction to complete 24 weeks treatment; AND
The treatment must provide no more than the balance of up to 24 weeks treatment available under the above restriction

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

Compliance with Written or Telephone Authority Required procedures


C4839

Severe psoriatic arthritis

Initial treatment – Initial 1 (new patient or patient recommencing treatment after a break of 5 years or more)

Patient must have severe active psoriatic arthritis; AND
Patient must have received no prior PBS-subsidised treatment with a biological agent for this condition; OR
Patient must have received no PBS-subsidised treatment with a biological agent for at least 5 years if they have previously received PBS-subsidised treatment with a biological agent for this condition; AND
Patient must have failed to achieve an adequate response to methotrexate at a dose of at least 20 mg weekly for a minimum period of 3 months; AND
Patient must have failed to achieve an adequate response to sulfasalazine at a dose of at least 2 g per day for a minimum period of 3 months; OR
Patient must have failed to achieve an adequate response to leflunomide at a dose of up to 20 mg daily for a minimum period of 3 months; AND
Patient must not receive more than 18 to 20 weeks of treatment, depending on the dosage regimen, under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab

Where treatment with methotrexate, sulfasalazine or leflunomide is contraindicated according to the relevant TGA-approved Product Information, details must be provided at the time of application

Where intolerance to treatment with methotrexate, sulfasalazine or leflunomide developed during the relevant period of use, which was of a severity to necessitate permanent treatment withdrawal, details of the degree of this toxicity must be provided at the time of application

The following initiation criteria indicate failure to achieve an adequate response and must be demonstrated in all patients at the time of the initial application:
an elevated erythrocyte sedimentation rate (ESR) greater than 25 mm per hour or a C-reactive protein (CRP) level greater than 15 mg per L; and either
(a) an active joint count of at least 20 active (swollen and tender) joints; or
(b) at least 4 active joints from the following list of major joints:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

If the above requirement to demonstrate an elevated ESR or CRP cannot be met, the application must state the reasons why this criterion cannot be satisfied
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement

Compliance with Written Authority Required procedures


C4842

Severe psoriatic arthritis

Initial treatment – Initial 2 (change or recommencement of treatment)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received prior PBS-subsidised treatment with a biological agent for this condition in this Treatment Cycle; AND
Patient must not have already failed, or ceased to respond to, PBS-subsidised treatment with 3 biological agents within this Treatment Cycle; AND
Patient must not have failed, or ceased to respond to, PBS-subsidised treatment with this drug during the current Treatment Cycle; AND
Patient must not receive more than 18 to 20 weeks of treatment, depending on the dosage regimen, under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form

Applications for a patient who has previously received PBS-subsidised treatment with this drug within this Treatment Cycle and who wishes to recommence therapy with this drug within this same Cycle, must be accompanied by evidence of a response to the patient's most recent course of PBS-subsidised treatment with this drug

Where the most recent course of PBS-subsidised treatment was approved under either of the initial treatment restrictions (i.e. for patients with no prior PBS-subsidised biological therapy or, under this restriction, for patients who have received previous PBS-subsidised biological therapy), the patient must have been assessed for response following a minimum of 12 weeks of therapy. This assessment must have been submitted no later than 4 weeks from the date that course was ceased

Where the most recent course of PBS-subsidised treatment with this drug was approved under the continuing treatment criteria, the patient must have been assessed for response, and the assessment submitted no later than 4 weeks from the date that course was ceased

Where a response assessment was not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment

An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

Compliance with Written Authority Required procedures


C4843

Severe psoriatic arthritis

Continuing treatment

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received this drug as their most recent course of PBS-subsidised treatment with a biological agent for this condition in the current Treatment Cycle; AND
Patient must demonstrate, at the time of application, an adequate response to treatment with this drug; AND
Patient must not receive more than 24 weeks of treatment per continuing treatment course authorised under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab

An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

The same indices of disease severity used to establish baseline at the commencement of treatment with each initial treatment application must be provided for all subsequent continuing treatment applications

All applications for continuing treatment with this drug must include a measurement of response to the most recent course of PBS-subsidised therapy. This assessment must be submitted no later than 4 weeks from the cessation of that treatment course. If the application is the first application for continuing treatment with this drug, it must be accompanied by an assessment of response to a minimum of 12 weeks of treatment with the initial treatment course

Where a response assessment is not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment with this drug

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form

Compliance with Written Authority Required procedures


(b)omit:

C4863

Severe psoriatic arthritis

Initial treatment - Initial 3 (initial PBS-subsidised supply for continuing treatment in a patient commenced on non-PBS-subsidised therapy)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have been receiving treatment with certolizumab pegol for this condition prior to 1 April 2015; AND
Patient must be receiving treatment with certolizumab pegol at the time of application; AND
Patient must have demonstrated a response to treatment as specified in the criteria for continuing PBS-subsidised treatment with certolizumab pegol; AND
Patient must not receive more than 24 weeks of treatment under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement

A patient may qualify for PBS-subsidised treatment under this restriction once only

Compliance with Written Authority Required procedures


(c)insert in numerical order after existing text

C6068

Severe psoriatic arthritis

Initial treatment – Initial 2 (change or recommencement of treatment)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received prior PBS-subsidised treatment with a biological agent for this condition in this Treatment Cycle; AND
Patient must not have already failed, or ceased to respond to, PBS-subsidised treatment with 3 biological agents within this Treatment Cycle; AND
Patient must not have failed, or ceased to respond to, PBS-subsidised treatment with this drug during the current Treatment Cycle; AND
Patient must not receive more than 18 to 20 weeks of treatment, depending on the dosage regimen, under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form.
Applications for a patient who has previously received PBS-subsidised treatment with this drug within this Treatment Cycle and who wishes to recommence therapy with this drug within this same Cycle, must be accompanied by evidence of a response to the patient's most recent course of PBS-subsidised treatment with this drug.
Where the most recent course of PBS-subsidised treatment was approved under either of the initial treatment restrictions (i.e. for patients with no prior PBS-subsidised biological therapy or, under this restriction, for patients who have received previous PBS-subsidised biological therapy), the patient must have been assessed for response following a minimum of 12 weeks of therapy. This assessment must have been submitted no later than 4 weeks from the date that course was ceased.
Where the most recent course of PBS-subsidised treatment with this drug was approved under the continuing treatment criteria, the patient must have been assessed for response, and the assessment submitted no later than 4 weeks from the date that course was ceased.
Where a response assessment was not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment.
An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and
either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).

Compliance with Written Authority Required procedures
C6109

Severe psoriatic arthritis

Initial treatment – Initial 1 (new patient or patient recommencing treatment after a break of 5 years or more)

Patient must have severe active psoriatic arthritis; AND
Patient must have received no prior PBS-subsidised treatment with a biological agent for this condition; OR
Patient must have received no PBS-subsidised treatment with a biological agent for at least 5 years if they have previously received PBS-subsidised treatment with a biological agent for this condition; AND
Patient must have failed to achieve an adequate response to methotrexate at a dose of at least 20 mg weekly for a minimum period of 3 months; AND
Patient must have failed to achieve an adequate response to sulfasalazine at a dose of at least 2 g per day for a minimum period of 3 months; OR
Patient must have failed to achieve an adequate response to leflunomide at a dose of up to 20 mg daily for a minimum period of 3 months; AND
Patient must not receive more than 18 to 20 weeks of treatment, depending on the dosage regimen, under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
Where treatment with methotrexate, sulfasalazine or leflunomide is contraindicated according to the relevant TGA-approved Product Information, details must be provided at the time of application.
Where intolerance to treatment with methotrexate, sulfasalazine or leflunomide developed during the relevant period of use, which was of a severity to necessitate permanent treatment withdrawal, details of the degree of this toxicity must be provided at the time of application.
The following initiation criteria indicate failure to achieve an adequate response and must be demonstrated in all patients at the time of the initial application:
an elevated erythrocyte sedimentation rate (ESR) greater than 25 mm per hour or a C-reactive protein (CRP) level greater than 15 mg per L; and
either
(a) an active joint count of at least 20 active (swollen and tender) joints; or
(b) at least 4 active joints from the following list of major joints:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).
If the above requirement to demonstrate an elevated ESR or CRP cannot be met, the application must state the reasons why this criterion cannot be satisfied.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement.

Compliance with Written Authority Required procedures
C6126

Severe psoriatic arthritis

Continuing treatment

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received this drug as their most recent course of PBS-subsidised treatment with a biological agent for this condition in the current Treatment Cycle; AND
Patient must demonstrate, at the time of application, an adequate response to treatment with this drug; AND
Patient must not receive more than 24 weeks of treatment per continuing treatment course authorised under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and
either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).
The same indices of disease severity used to establish baseline at the commencement of treatment with each initial treatment application must be provided for all subsequent continuing treatment applications.
All applications for continuing treatment with this drug must include a measurement of response to the most recent course of PBS-subsidised therapy. This assessment must be submitted no later than 4 weeks from the cessation of that treatment course. If the application is the first application for continuing treatment with this drug, it must be accompanied by an assessment of response to a minimum of 12 weeks of treatment with the initial treatment course.
Where a response assessment is not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment with this drug.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form.

Compliance with Written Authority Required procedures
  1. Schedule 4, Part 1, entry for Cromoglycic Acid

    substitute:

Cromoglycic acid C6088 Vernal kerato-conjunctivitis
  1. Schedule 4, Part 1, entry for Esomeprazole and clarithromycin and amoxycillin

    substitute:

Esomeprazole and clarithromycin and amoxycillin C6118

Eradication of Helicobacter pylori

The condition must be associated with peptic ulcer disease.

  1. Schedule 4, Part 1, entry for Etanercept

    (a)omit:

C4826 P4826

Severe psoriatic arthritis

Initial treatment – Initial 1 (new patient or patient recommencing treatment after a break of 5 years or more)

Patient must have severe active psoriatic arthritis; AND
Patient must have received no prior PBS-subsidised treatment with a biological agent for this condition; OR
Patient must have received no PBS-subsidised treatment with a biological agent for at least 5 years if they have previously received PBS-subsidised treatment with a biological agent for this condition; AND
Patient must have failed to achieve an adequate response to methotrexate at a dose of at least 20 mg weekly for a minimum period of 3 months; AND
Patient must have failed to achieve an adequate response to sulfasalazine at a dose of at least 2 g per day for a minimum period of 3 months; OR
Patient must have failed to achieve an adequate response to leflunomide at a dose of up to 20 mg daily for a minimum period of 3 months; AND
Patient must not receive more than 16 weeks of treatment under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab.
Where treatment with methotrexate, sulfasalazine or leflunomide is contraindicated according to the relevant TGA-approved Product Information, details must be provided at the time of application

Where intolerance to treatment with methotrexate, sulfasalazine or leflunomide developed during the relevant period of use, which was of a severity to necessitate permanent treatment withdrawal, details of the degree of this toxicity must be provided at the time of application

The following initiation criteria indicate failure to achieve an adequate response and must be demonstrated in all patients at the time of the initial application:
an elevated erythrocyte sedimentation rate (ESR) greater than 25 mm per hour or a C-reactive protein (CRP) level greater than 15 mg per L; and either
(a) an active joint count of at least 20 active (swollen and tender) joints; or
(b) at least 4 active joints from the following list of major joints:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

If the above requirement to demonstrate an elevated ESR or CRP cannot be met, the application must state the reasons why this criterion cannot be satisfied

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement

Compliance with Written Authority Required procedures


C4840 P4840

Severe psoriatic arthritis

Initial treatment – Initial 2 (change or recommencement of treatment)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received prior PBS-subsidised treatment with a biological agent for this condition in this Treatment Cycle; AND
Patient must not have already failed, or ceased to respond to, PBS-subsidised treatment with 3 biological agents within this Treatment Cycle; AND
Patient must not have failed, or ceased to respond to, PBS-subsidised treatment with this drug during the current Treatment Cycle; AND
Patient must not receive more than 16 weeks of treatment under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form

Applications for a patient who has previously received PBS-subsidised treatment with this drug within this Treatment Cycle and who wishes to recommence therapy with this drug within this same Cycle, must be accompanied by evidence of a response to the patient's most recent course of PBS-subsidised treatment with this drug

Where the most recent course of PBS-subsidised treatment was approved under either of the initial treatment restrictions (i.e. for patients with no prior PBS-subsidised biological therapy or, under this restriction, for patients who have received previous PBS-subsidised biological therapy), the patient must have been assessed for response following a minimum of 12 weeks of therapy. This assessment must have been submitted no later than 4 weeks from the date that course was ceased

Where the most recent course of PBS-subsidised treatment with this drug was approved under the continuing treatment criteria, the patient must have been assessed for response, and the assessment submitted no later than 4 weeks from the date that course was ceased

Where a response assessment was not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment

An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

Compliance with Written Authority Required procedures


(b)omit:

C4864 P4864

Severe psoriatic arthritis

Continuing treatment

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received this drug as their most recent course of PBS-subsidised treatment with a biological agent for this condition in the current Treatment Cycle; AND
Patient must demonstrate, at the time of application, an adequate response to treatment with this drug; AND
Patient must not receive more than 24 weeks of treatment per continuing treatment course authorised under this restriction

Patient must be an adult

Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis

For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab or infliximab

An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth)

The same indices of disease severity used to establish baseline at the commencement of treatment with each initial treatment application must be provided for all subsequent continuing treatment applications

All applications for continuing treatment with this drug must include a measurement of response to the most recent course of PBS-subsidised therapy. This assessment must be submitted no later than 4 weeks from the cessation of that treatment course. If the application is the first application for continuing treatment with this drug, it must be accompanied by an assessment of response to a minimum of 12 weeks of treatment with the initial treatment course

Where a response assessment is not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment with this drug

The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form

Compliance with Written Authority Required procedures


(c)insert in numerical order after existing text:

C6073 P6073 Severe dry eye syndrome, including Sjogren's syndrome
C6098 P6098

Severe dry eye syndrome, including Sjogren's syndrome

Patient must be receiving treatment under a GP Management Plan or Team Care Arrangements where Medicare benefits were or are payable for the preparation of the Plan or coordination of the Arrangements.

C6120 Severe dry eye syndrome, including Sjogren's syndrome
  1. Schedule 4, Part 1, entry for Polyvinyl Alcohol

    substitute:

Polyvinyl alcohol C6073 P6073 Severe dry eye syndrome, including Sjogren's syndrome
C6098 P6098 Severe dry eye syndrome, including Sjogren's syndrome
Patient must be receiving treatment under a GP Management Plan or Team Care Arrangements where Medicare benefits were or are payable for the preparation of the Plan or coordination of the Arrangements.
C6120 Severe dry eye syndrome, including Sjogren's syndrome
  1. Schedule 4, Part 1, entry for Prednisolone with Phenylephrine

    substitute:

Prednisolone with phenylephrine C6080 Corneal grafts
C6087 Uveitis
C6101 Uveitis
  1. Schedule 4, Part 1, entry for Risperidone

    omit:

C5897 P5897

Behavioural disturbances

The condition must be characterised by psychotic symptoms and aggression; AND
Patient must have dementia; AND
Patient must have failed to respond to non-pharmacological methods of treatment.

Compliance with Authority Required procedures - Streamlined Authority Code 5897
  1. Schedule 4, Part 1, omit entry for Tiludronic Acid

  2. Schedule 4, Part 1, entry for Trastuzumab emtansine

    (a)omit:

C4987

Metastatic (Stage IV) HER2 positive breast cancer

Initial treatment

Patient must have evidence of human epidermal growth factor receptor 2 (HER2) gene amplification as demonstrated by in situ hybridisation (ISH) either in the primary tumour or a metastatic lesion; AND
The condition must have progressed following treatment with pertuzumab and trastuzumab in combination; OR
The condition must have progressed during or within 6 months of completing adjuvant therapy with trastuzumab; AND
Patient must have a WHO performance status of 0 or 1; AND
The treatment must be as monotherapy; AND
Patient must not have received prior treatment with lapatinib; OR
Patient must have developed intolerance to lapatinib of a severity necessitating permanent treatment withdrawal; AND
The treatment must not be used in a patient with a left ventricular ejection fraction (LVEF) of less than 45% and/or with symptomatic heart failure

Authority applications for initial treatment must be made in writing and must include:
(a) a completed authority prescription form; and
(b) a completed Late stage metastatic breast cancer Initial PBS authority application form which includes:
(i) a copy of the pathology report from an Approved Pathology Authority confirming evidence of HER2 gene amplification in the primary tumour or a metastatic lesion by in situ hybridisation (ISH) and tick a box to state the person has Stage IV disease;
(ii) a copy of the signed patient acknowledgement form;
(iii) dates of treatment with trastuzumab and pertuzumab; and
(iv) date of demonstration of progression whilst on treatment with trastuzumab and pertuzumab; or
(v) date of demonstration of progression and date of completion of adjuvant trastuzumab treatment

Cardiac function must be tested by echocardiography (ECHO) or multigated acquisition (MUGA), prior to seeking the initial authority approval and then at 3 monthly intervals during treatment

Patients who have progressive disease on lapatinib are not eligible to receive PBS-subsidised trastuzumab emtansine

Patients who have developed intolerance to lapatinib of a severity necessitating permanent treatment withdrawal are eligible to receive PBS-subsidised trastuzumab emtansine

If intolerance to treatment develops during the relevant period of use, which is of a severity necessitating permanent treatment withdrawal, please provide details of the degree of this toxicity at the time of application

Compliance with Written Authority Required procedures


(b)insert in numerical order after existing text:

C6096

Metastatic (Stage IV) HER2 positive breast cancer

Initial treatment

Patient must have evidence of human epidermal growth factor receptor 2 (HER2) gene amplification as demonstrated by in situ hybridisation (ISH) either in the primary tumour or a metastatic lesion; AND
The condition must have progressed following treatment with pertuzumab and trastuzumab in combination; OR
The condition must have progressed during or within 6 months of completing adjuvant therapy with trastuzumab; AND
Patient must have a WHO performance status of 0 or 1; AND
The treatment must be as monotherapy; AND
The treatment must not be used in a patient with a left ventricular ejection fraction (LVEF) of less than 45% and/or with symptomatic heart failure.
Authority applications for initial treatment must be made in writing and must include:
(a) a completed authority prescription form; and
(b) a completed Late stage metastatic breast cancer Initial PBS authority application form which includes:
(i) a copy of the pathology report from an Approved Pathology Authority confirming evidence of HER2 gene amplification in the primary tumour or a metastatic lesion by in situ hybridisation (ISH) and tick a box to state the person has Stage IV disease;
(ii) a copy of the signed patient acknowledgement form;
(iii) dates of treatment with trastuzumab and pertuzumab; and
(iv) date of demonstration of progression whilst on treatment with trastuzumab and pertuzumab; or
(v) date of demonstration of progression and date of completion of adjuvant trastuzumab treatment.
Cardiac function must be tested by echocardiography (ECHO) or multigated acquisition (MUGA), prior to seeking the initial authority approval and then at 3 monthly intervals during treatment.
If intolerance to treatment develops during the relevant period of use, which is of a severity necessitating permanent treatment withdrawal, please provide details of the degree of this toxicity at the time of application.

Compliance with Written Authority Required procedures
C6129

Metastatic (Stage IV) HER2 positive breast cancer

Initial treatment

Patient must have evidence of human epidermal growth factor receptor 2 (HER2) gene amplification as demonstrated by in situ hybridisation (ISH) either in the primary tumour or a metastatic lesion; AND
The condition must have progressed following treatment with pertuzumab and trastuzumab in combination; OR
The condition must have progressed during or within 6 months of completing adjuvant therapy with trastuzumab; AND
Patient must have a WHO performance status of 0 or 1; AND
The treatment must be as monotherapy; AND
The treatment must not be used in a patient with a left ventricular ejection fraction (LVEF) of less than 45% and/or with symptomatic heart failure.
Authority applications for initial treatment must be made in writing and must include:
(a) a completed authority prescription form; and
(b) a completed Late stage metastatic breast cancer Initial PBS authority application form which includes:
(i) a copy of the pathology report from an Approved Pathology Authority confirming evidence of HER2 gene amplification in the primary tumour or a metastatic lesion by in situ hybridisation (ISH) and tick a box to state the person has Stage IV disease;
(ii) a copy of the signed patient acknowledgement form;
(iii) dates of treatment with trastuzumab and pertuzumab; and
(iv) date of demonstration of progression whilst on treatment with trastuzumab and pertuzumab; or
(v) date of demonstration of progression and date of completion of adjuvant trastuzumab treatment.
Cardiac function must be tested by echocardiography (ECHO) or multigated acquisition (MUGA), prior to seeking the initial authority approval and then at 3 monthly intervals during treatment.
If intolerance to treatment develops during the relevant period of use, which is of a severity necessitating permanent treatment withdrawal, please provide details of the degree of this toxicity at the time of application.

Compliance with Written Authority Required procedures
  1. Schedule 4, Part 1, entry for Ustekinumab

    insert in numerical order after existing text:

C6067 P6067

Severe psoriatic arthritis

Continuing treatment

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received this drug as their most recent course of PBS-subsidised treatment with a biological agent for this condition in the current Treatment Cycle; AND
Patient must demonstrate, at the time of application, an adequate response to treatment with this drug; AND
Patient must not receive more than 24 weeks of treatment per continuing treatment course authorised under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and
either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).
The same indices of disease severity used to establish baseline at the commencement of treatment with each initial treatment application must be provided for all subsequent continuing treatment applications.
All applications for continuing treatment with this drug must include a measurement of response to the most recent course of PBS-subsidised therapy. This assessment must be submitted no later than 4 weeks from the cessation of that treatment course. If the application is the first application for continuing treatment with this drug, it must be accompanied by an assessment of response to a minimum of 12 weeks of treatment with the initial treatment course.
Where a response assessment is not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment with this drug.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form.

Compliance with Written Authority Required procedures
C6091 P6091

Severe psoriatic arthritis

Initial treatment – Initial 1 (new patient or patient recommencing treatment after a break of 5 years or more)

Patient must have severe active psoriatic arthritis; AND
Patient must have received no prior PBS-subsidised treatment with a biological agent for this condition; OR
Patient must have received no PBS-subsidised treatment with a biological agent for at least 5 years if they have previously received PBS-subsidised treatment with a biological agent for this condition; AND
Patient must have failed to achieve an adequate response to methotrexate at a dose of at least 20 mg weekly for a minimum period of 3 months; AND
Patient must have failed to achieve an adequate response to sulfasalazine at a dose of at least 2 g per day for a minimum period of 3 months; OR
Patient must have failed to achieve an adequate response to leflunomide at a dose of up to 20 mg daily for a minimum period of 3 months; AND
Patient must not receive more than 28 weeks of treatment under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
Where treatment with methotrexate, sulfasalazine or leflunomide is contraindicated according to the relevant TGA-approved Product Information, details must be provided at the time of application.
Where intolerance to treatment with methotrexate, sulfasalazine or leflunomide developed during the relevant period of use, which was of a severity to necessitate permanent treatment withdrawal, details of the degree of this toxicity must be provided at the time of application.
The following initiation criteria indicate failure to achieve an adequate response and must be demonstrated in all patients at the time of the initial application:
an elevated erythrocyte sedimentation rate (ESR) greater than 25 mm per hour or a C-reactive protein (CRP) level greater than 15 mg per L; and
either
(a) an active joint count of at least 20 active (swollen and tender) joints; or
(b) at least 4 active joints from the following list of major joints:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).
If the above requirement to demonstrate an elevated ESR or CRP cannot be met, the application must state the reasons why this criterion cannot be satisfied.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement.

Compliance with Written Authority Required procedures
C6108 P6108

Severe psoriatic arthritis

Initial treatment – Initial 2 (change or recommencement of treatment)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have received prior PBS-subsidised treatment with a biological agent for this condition in this Treatment Cycle; AND
Patient must not have already failed, or ceased to respond to, PBS-subsidised treatment with 3 biological agents within this Treatment Cycle; AND
Patient must not have failed, or ceased to respond to, PBS-subsidised treatment with this drug during the current Treatment Cycle; AND
Patient must not receive more than 28 weeks of treatment under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form.
Applications for a patient who has previously received PBS-subsidised treatment with this drug within this Treatment Cycle and who wishes to recommence therapy with this drug within this same Cycle, must be accompanied by evidence of a response to the patient's most recent course of PBS-subsidised treatment with this drug.
Where the most recent course of PBS-subsidised treatment was approved under either of the initial treatment restrictions (i.e. for patients with no prior PBS-subsidised biological therapy or, under this restriction, for patients who have received previous PBS-subsidised biological therapy), the patient must have been assessed for response following a minimum of 12 weeks of therapy. This assessment must have been submitted no later than 4 weeks from the date that course was ceased.
Where the most recent course of PBS-subsidised treatment with this drug was approved under the continuing treatment criteria, the patient must have been assessed for response, and the assessment submitted no later than 4 weeks from the date that course was ceased.
Where a response assessment was not submitted within these timeframes, the patient will be deemed to have failed to respond to treatment.
An adequate response to treatment is defined as:
an erythrocyte sedimentation rate (ESR) no greater than 25 mm per hour or a C-reactive protein (CRP) level no greater than 15 mg per L or either marker reduced by at least 20% from baseline; and
either of the following:
(a) a reduction in the total active (swollen and tender) joint count by at least 50% from baseline, where baseline is at least 20 active joints; or
(b) a reduction in the number of the following major active joints, from at least 4, by at least 50%:
(i) elbow, wrist, knee and/or ankle (assessed as swollen and tender); and/or
(ii) shoulder and/or hip (assessed as pain in passive movement and restriction of passive movement, where pain and limitation of movement are due to active disease and not irreversible damage such as joint destruction or bony overgrowth).

Compliance with Written Authority Required procedures
C6125 P6125

Severe psoriatic arthritis

Initial treatment - Initial 3 (initial PBS-subsidised supply for continuing treatment in a patient commenced on non-PBS-subsidised therapy)

Patient must have a documented history of severe active psoriatic arthritis; AND
Patient must have been receiving treatment with this drug for this condition prior to 1 May 2016; AND
Patient must be receiving treatment with this drug for this condition at the time of application; AND
Patient must have demonstrated a response to treatment as specified in the criteria for continuing PBS-subsidised treatment with this drug; AND
Patient must not receive more than 24 weeks of treatment under this restriction.
Patient must be an adult.
Must be treated by a rheumatologist; OR
Must be treated by a clinical immunologist with expertise in the management of psoriatic arthritis.
For the purposes of this restriction 'biological agent' means adalimumab, certolizumab pegol, etanercept, golimumab, infliximab or ustekinumab.
The authority application must be made in writing and must include:
(1) a completed authority prescription form; and
(2) a completed Psoriatic Arthritis PBS Authority Application - Supporting Information Form; and
(3) a signed patient acknowledgement.
A patient may qualify for PBS-subsidised treatment under this restriction once only.

Compliance with Written Authority Required procedures
  1. Schedule 4, Part 1, entry for Verteporfin

    substitute:

Verteporfin C6099

Subfoveal choroidal neovascularisation (CNV)

Initial treatment

The condition must be predominantly classic (greater than or equal to 50%); AND
The treatment must be the sole PBS-subsidised therapy for this condition; AND
The condition must be due to age-related macular degeneration (AMD); AND
The condition must be diagnosed by fluorescein angiography; AND
Patient must have a baseline visual acuity equal to or better than 6/60 (20/200).
Must be treated by an ophthalmologist.
The first authority application for each eye must be made in writing or by telephone.
A written application must include:
a) a completed authority prescription form;
b) a completed Subfoveal Choroidal Neovascularisation (CNV) - PBS Supporting Information Form; and
c) a copy of the fluorescein angiogram demonstrating that the CNV is predominantly classic (greater than or equal to 50%).
A telephone application must be made following submission by facsimile of a copy of a completed Subfoveal Choroidal Neovascularisation (CNV) - PBS Supporting Information Form and a copy of the fluorescein angiogram. The original documentation must be submitted to the Chief Executive Medicare by post after the application has been authorised.

Compliance with Written or Telephone Authority Required procedures
C6100

Subfoveal choroidal neovascularisation (CNV)

Initial PBS-subsidised treatment

The condition must be predominantly classic (greater than or equal to 50%); AND
The condition must be due to macular degeneration; AND
Patient must have been authorised by the Angiogram Review Panel to receive treatment with verteporfin in the same eye under the MBS Visudyne Therapy Program; AND
The treatment must be the sole PBS-subsidised therapy for this condition.
Must be treated by a ophthalmologist.
The first authority application for each eye must be made in writing or by telephone.
A written application must include:
(a) a completed authority prescription form; and
(b) a completed Subfoveal Choroidal Neovascularisation (CNV) - PBS Supporting Information Form, which includes the date of review by the Angiogram Review Panel and the number of treatments administered in that eye under the MBS Visudyne Therapy Program; and
(c) a copy of the fluorescein angiogram demonstrating that the CNV is predominantly classic (greater than or equal to 50%).
A telephone application must be made following submission by facsimile of a copy of a completed Subfoveal Choroidal Neovascularisation (CNV) - PBS Supporting Information Form and a copy of the fluorescein angiogram. The original documentation must be submitted to the Chief Executive Medicare by post after the application has been authorised.

Compliance with Written or Telephone Authority Required procedures
C6121

Subfoveal choroidal neovascularisation (CNV)

Continuing treatment

The condition must be predominantly classic (greater than or equal to 50%); AND
The condition must be due to macular degeneration; AND
The treatment must be the sole PBS-subsidised therapy for this condition; AND
Patient must have previously been granted an authority prescription for the same eye.
Must be treated by an ophthalmologist.

Compliance with Written or Telephone Authority Required procedures
  1. Schedule 4, Part 3

    substitute:

Part 3General statement for drugs for the treatment of hepatitis C

1  Criteria for eligibility for drugs for the treatment of chronic hepatitis C

The criteria for patient eligibility for drugs for the treatment of chronic hepatitis C are that:

  1. the patient is 18 years or older; and

  2. the patient has been assessed in accordance with paragraph 2 of this Part; and

  3. the patient is:

    a.treated by a medical practitioner who is experienced in the treatment of patients with chronic hepatitis C infection and is:

    i.a gastroenterologist; or

    ii.a hepatologist; or

    iii.an infectious diseases physician; or

    b.treated in consultation with a medical practitioner who is experienced in the treatment of patients with chronic hepatitis C infection and who is:

    i.a gastroenterologist; or

    ii.a hepatologist; or

    iii.an infectious diseases physician

2  Assessment of patient

For the purpose of subparagraph 1(2) of this Part, the patient has been assessed if the treating medical practitioner has:

  1. documented the following information in the patient’s medical records:

    a.evidence of chronic hepatitis C infection; and

    b.evidence of the patient’s hepatitis C virus genotype; and

  2. chosen a regimen in accordance with paragraph 3 of this Part; and

  3. collected the following information for the purposes of the authority application:

    a.the patient’s hepatitis C virus genotype; and

    b.whether the patient is:

    i. cirrhotic; or

    ii. Non-cirrhotic

  4. In this paragraph, evidence of chronic hepatitis C infection is documentation of:

    a.repeat test results showing antibody to hepatitis C virus (anti-HCV) positive; and

    b.test result showing hepatitis C virus ribonucleic acid (RNA) positive

3  Treatment regimen

For the purpose of subparagraph 2(2) of this Part, the treating medical practitioner has chosen a regimen in accordance with this paragraph if the patient:

  1. is a kind of patient mentioned for an Item in column 2 of the following table; and

  2. is to receive one of the regimens mentioned in column 3 of the same Item of the following table

Item Kind of patient Regimen
1

Patient:

(a)     with Genotype 1; and

(b)     who is treatment naïve; and

(c)     who is non-cirrhotic

Either:

(a)     LEDIPASVIR with SOFOSBUVIR for 8 weeks; or

(b)     LEDIPASVIR with SOFOSBUVIR for 12 weeks; or

(c)     DACLATASVIR and SOFOSBUVIR for 12 weeks; or

(d)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks; or

(e)     PARITAPREVIR with RITONAVIR with OMBITASVIR and DASABUVIR for 12 weeks; or

(f)   PARITAPREVIR with RITONAVIR with OMBITASVIR and DASABUVIR and RIBAVIRIN for 12 weeks.

2

Patient:

(a)     with Genotype 1; and

(b)     who is treatment experienced; and

(c)     who is non-cirrhotic

Either:

(a)     LEDIPASVIR with SOFOSBUVIR for 12 weeks; or

(b)     DACLATASVIR and SOFOSBUVIR for 12 weeks; or

(c)     DACLATASVIR and SOFOSBUVIR for 24 weeks; or

(d)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks; or

(e)     PARITAPREVIR with RITONAVIR with OMBITASVIR and DASABUVIR for 12 weeks; or

(f)   PARITAPREVIR with RITONAVIR with OMBITASVIR and DASABUVIR and RIBAVIRIN for 12 weeks.

3

Patient:

(a)     with Genotype 2; and

(b)     who is treatment naïve; and

(c)     who is non-cirrhotic

SOFOSBUVIR and RIBAVIRIN for 12 weeks.

4

Patient:

(a)     with Genotype 2; and

(b)     who is treatment experienced; and

(c)     who is non-cirrhotic

SOFOSBUVIR and RIBAVIRIN for 12 weeks.

5

Patient:

(a)     with Genotype 3; and

(b)     who is treatment naïve; and

(c)     who is non-cirrhotic

Either:

(a)     DACLATASVIR and SOFOSBUVIR for 12 weeks; or

(b)     SOFOSBUVIR and RIBAVIRIN for 24 weeks; or

(c)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

6

Patient:

(a)     with Genotype 3; and

(b)     who is treatment experienced; and

(c)     who is non-cirrhotic

Either:

(a)     DACLATASVIR and SOFOSBUVIR for 12 weeks; or

(b)     SOFOSBUVIR and RIBAVIRIN for 24 weeks; or

(c)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

7

Patient:

(a)     with:

(i)    Genotype 4; or

(ii)     Genotype 5; or

(iii)    Genotype 6; and

(b)     who is treatment naïve; and

(c)     who is non-cirrhotic

SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

8

Patient:

(a)     with:

(i)    Genotype 4; or

(ii)     Genotype 5; or

(iii)    Genotype 6; and

(b)     who is treatment experienced; and

(c)     who is non-cirrhotic

SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

9

Patient:

(a)     with Genotype 1; and

(b)   who is treatment naïve; and

(c)    who is cirrhotic

Either:

(a)     LEDIPASVIR with SOFOSBUVIR for 12 weeks; or

(b)     DACLATASVIR and SOFOSBUVIR and RIBAVIRIN for 12 weeks; or

(c)     DACLATASVIR and SOFOSBUVIR for 24 weeks; or

(d)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks; or

(e)     PARITAPREVIR with RITONAVIR with OMBITASVIR and DASABUVIR and RIBAVIRIN for 12 weeks.

10

Patient:

(a)     with Genotype 1; and

(b)     who is treatment experienced; and

(c)     who is cirrhotic

Either:

(a)     LEDIPASVIR with SOFOSBUVIR for 24 weeks; or

(b)     DACLATASVIR and SOFOSBUVIR for 24 weeks; or

(c)     DACLATASVIR and SOFOSBUVIR and RIBAVIRIN for 12 weeks; or

(d)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks; or

(e)     PARITAPREVIR with RITONAVIR with OMBITASVIR and DASABUVIR and RIBAVIRIN for 12 weeks; or

(f)   PARITAPREVIR with RITONAVIR with OMBITASVIR and DASABUVIR and RIBAVIRIN for 24 weeks.

11

Patient:

(a)     with Genotype 2; and

(b)     who is treatment naïve; and

(c)     who is cirrhotic

SOFOSBUVIR and RIBAVIRIN for 12 weeks.

12

Patient:

(a)     with Genotype 2; and

(b)     who is treatment experienced; and

(c)     who is cirrhotic

SOFOSBUVIR and RIBAVIRIN for 12 weeks.

13

Patient:

(a)     with Genotype 3; and

(b)     who is treatment naïve; and

(c)     who is cirrhotic

Either:

(a)     SOFOSBUVIR and RIBAVIRIN for 24 weeks; or

(b)     DACLATASVIR and SOFOSBUVIR for 24 weeks; or

(c)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

14

Patient:

(a)     with Genotype 3; and

(b)     who is treatment experienced; and

(c)     who is cirrhotic

Either:

(a)     DACLATASVIR and SOFOSBUVIR for 24 weeks; or

(b)     SOFOSBUVIR and RIBAVIRIN for 24 weeks; or

(c)     SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

15

Patient:

(a)     with:

(i)    Genotype 4; or

(ii)     Genotype 5; or

(iii)    Genotype 6; and

(b)   who is treatment naïve; and

(c)    who is cirrhotic

SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

16

Patient:

(a)     with:

(i)    Genotype 4; or

(ii)     Genotype 5; or

(iii)    Genotype 6; and

(b)   who is treatment experienced; and

(c)    who is cirrhotic

SOFOSBUVIR and PEGINTERFERON ALFA-2A with RIBAVIRIN for 12 weeks.

  1. Schedule 5, entry for Esomeprazole in each of the forms: Tablet (enteric coated) 20 mg (as magnesium trihydrate); and Tablet (enteric coated) 40 mg (as magnesium trihydrate)

    insert in alphabetical order in the column headed “Brand”:   Nexazole

  2. Schedule 5, after entry for Esomeprazole

    insert:

Esomeprazole and Clarithromycin and Amoxycillin GRP-20639 Pack containing 14 tablets (enteric coated) containing esomeprazole 20 mg (as magnesium), 14 tablets clarithromycin 500 mg and 28 capsules amoxycillin 500 mg (as trihydrate) Oral ESOMEPRAZOLE SANDOZ Hp7
Pack containing 14 tablets (enteric coated) containing esomeprazole 20 mg (as magnesium trihydrate), 14 tablets clarithromycin 500 mg and 28 capsules amoxycillin 500 mg (as trihydrate) Oral Nexium Hp7
  1. Schedule 5, entry for Olanzapine in the form Tablet 2.5 mg

    omit from the column headed “Brand”:       Olanzapine-GA 8170B   substitute:             Olanzapine-GA

  2. Schedule 5, entry for Olanzapine in the form Tablet 5 mg

    (a)omit from the column headed “Brand”:           Terry White Chemists Olanzapine 8185T substitute:         Terry White Chemists Olanzapine

    (b)omit from the column headed “Brand”:           Zypine 8185T    substitute:             Zypine

    (c)omit from the column headed “Brand”:           Zyprexa 8185T  substitute:             Zyprexa

  3. Schedule 5, entry for Olanzapine in the form Tablet 10 mg

    (a)omit from the column headed “Brand”:           Olanzacor 10 8187X      substitute:             Olanzacor 10

    (b)omit from the column headed “Brand”:           Olanzapine-GA 8187X               substitute:             Olanzapine-GA

  4. Schedule 5, entry for Ondansetron in each of the forms: Wafer 4 mg; and Wafer 8 mg

    omit from the column headed “Brand”:       Ondaz Zydis

  5. Schedule 5, entry for Rizatriptan in the form Tablet (orally disintegrating) 10 mg (as benzoate)

    (a)insert in alphabetical order in the column headed “Brand”:       APO-Rizatriptan

    (b)insert in alphabetical order in the column headed “Brand”:       Chem mart Rizatriptan

    (c)insert in alphabetical order in the column headed “Brand”:       Terry White Chemists Rizatriptan

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